Saussurea lappa extract modulates cell mediated and humoral immune response in mice

In the present study immunopharmacological properties of hydroalcoholic extract of Saussurea lappa C.B. Clarke root have been investigated. After administration of extract in doses of 100 and 200 mg/kg body weight a significant increase in leukocyte count, spleen weight, phagocytic index and antibody secreting cells were noticed. Treatment with extract enhanced DTH reaction, which is reflected from the increased footpad thickness. Saussurea lappa extract treatment also reduced the total number of animals showing anaphylactic symptoms. At the low dose (100 mg/kg) Saussurea lappa extract did not affect the humoral immune response but at higher dose (200 mg/kg) produced a significant enhancement in antibody titre value. The results suggest that bio active compound of Saussurea lappa influences both humoral as well as cell mediated immune system.